Description
Title: Hyaluronan’s Immunologic Functions in the Healing of Dermal Wounds
Abstract: Hyaluronic acid (HA), a glycosaminoglycan that is found in abundance in the skin, has gained attention recently for its ability to speed up the healing of dermal wounds. Particularly, the effects of HA are determined by the length of linearly repeating disaccharides, or molecular weight (MW). While low molecular weight (LMW)-HA contributes to inflammation and immunostimulation, high molecular weight (HMW)-HA has an anti-inflammatory and immunosuppressive effect. Direct and indirect interactions between HA and the innate and adaptive immune systems are of particular interest during the inflammatory stage of tissue repair due to their long-lasting effects on wound healing. With a focus on HA’s involvement in the immune subsystems, this review aims to synthesize the literature on wound healing.
Keywords: adaptive immunity; hyaluronic acid (HA); immunology; innate immunity; molecular weight (MW); wound healing
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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