Description
Title: Hyaluronan Aggregation in Various Human Organs: Densification
Abstract: Complex biological functions of hyaluronan (HA) have sparked clinical interest in a number of medical specialties. We give an overview of HA aggregation, also known as densification, in human organs in this narrative review. According to the literature, HA can aggregate in the liver, pancreatic cancer, malignant melanoma, blood vessel, muscle, fascia, skin, eye, lung, and kidney cancer. Aggregation of HA causes an increase in extracellular matrix viscosity, which results in stiffness and organ dysfunction in all of these organs. Some of these organs may also experience fibrosis as a direct result of long-term densification. Using specific imaging tests like dynamic ultrasonography, elastosonography, elasto-MRI, and T1 MRI, the clinician can organize the treatment plan and make an early diagnosis to stop the pathology and dysfunction from progressing further.
Keywords: densification; hyaluronan; aggregation; liver; kidney; fascia; blood vessels; eye; skin; lung; muscle
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Bioengineering
Writer Experience: 20+ Years
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