Research paper on How Cell Death is Affected by Inflammation Pathways in Neuro-Muscular Disorders

Description

Title: How Cell Death is Affected by Inflammation Pathways in Neuro-Muscular Disorders

Abstract: Neuro-muscular disorders are a group of illnesses caused by genetic mutations that cause muscle weakness and waste, as well as difficulties breathing and swallowing. However, specific molecular and cellular mechanisms involved in muscle changes and nerve depletions cause the loss of motor-nerve or skeletal-muscle function, frequently as a result of an excessive cell death. Apoptosis appears to be upregulated in many of these disorders, which significantly contributes to the pathology, according to morphological and molecular studies. Some cellular processes that take place during diseases, such as mitochondrial dysfunction, protein aggregation, free radical generation, excitotoxicity, and inflammation, have the potential to result in cell death. The latter is a key player in disease progression and is known as neuroinflammation in the central nervous system. It is characterized by reactive microglia and astrocytes as well as the infiltration of peripheral monocytes and lymphocytes. Reactive oxygen species buildup, which results in mitochondrial genomic and respiratory chain instability, autophagy dysfunction, and ultimately neuronal or muscle cell death, are some of the mechanisms underlying inflammation. This review discusses the primary inflammatory pathways that play a role in cell death in neuro-muscular disorders by emphasizing the key mechanisms. Understanding these mechanisms appears to be crucial for the development of therapeutic approaches to stop the ensuing neuron loss and muscle atrophy.

Keywords: neuro-muscular diseases; motor neuron disorders; innate immune system; neuroinflammation;cell death

Paper Quality: SCOPUS / Web of Science Level Research Paper

Subject: Biomolecules

Writer Experience: 20+ Years

Plagiarism Report: Turnitin Plagiarism Report will be less than 10%

Restriction: Only one author may purchase a single paper. The paper will then indicate that it is out of stock.

What will I get after the purchase?

A turnitin plagiarism report of less than 10% in a pdf file and a full research paper in a word document.

In case you have any questions related to this research paper, please feel free to call/ WhatsApp on +919726999915