Description
Title: HemoTypeSC Test for Rapid Sickle Cell Disease Screening in Cote d’Ivoire Feasibility Study
Abstract: Black people are disproportionately affected by the hereditary disease sickle cell disease. The prevalence of hemoglobin S affects at least 10% of the population in West Africa and can reach 40% in Central Africa, which is the Lehmann “sickle belt” level of sub-Saharan Africa. Hemoglobin S is prevalent in the general population of Cote d’Ivoire at 12–14%, and among children in Abidjan at 11.71%. On the other hand, it may also result in composite heterogeneous sickle cell disease, such as SC or S/-thalassemia in this study, when it coexists with other hemoglobin phenotypes like AC (6.2%) and -thalassemia (2.7%) traits. Sickle cell disease has been acknowledged as a public health issue since 2009, but despite the advancements made, much work still needs to be done. Therefore, the goal of this study is to encourage quick screening for people in Cote d’Ivoire who are battling sickle cell disease. 336 children were involved in the study, of whom 236 were recruited as “all-comers” in the municipality of Treichville in Abidjan, and 100 other children with known hemoglobin phenotypes were followed up in the Hematology Department of the University Hospital of Treichville. The study was conducted over a 6-month period (April to September 2019). HemoTypeSCTM for quick screening and hemoglobin electrophoresis, the standard procedure for confirming the diagnosis in the lab, were the two tests used. The results demonstrated the HemoTypeSCTM’s accuracy in detecting hemoglobin A, S, and C, with 100% sensitivity and specificity. On the other hand, when we analyze all 336 of the children together, including the cases where HbF was found by hemoglobin electrophoresis, these sensitivity and specificity fall to 98.2% and 99.7%, respectively. Therefore, it is crucial to conduct certainty tests after the HemoTypeSCTM screening test in order to identify the precise phenotypes and proportions of the different types of hemoglobin. 15% of the 236 children of all-comers in subgroup 1 had hemoglobin S. HemoTypeSCTM offers quick detection of hemoglobin phenotypes HbAA, HbSS, HbSC, HbCC, HbAS, and HbAC. as a result, it is dependable, affordable, and disposable for quick screening and early detection of sickle cell disease in Cote d’Ivoire.
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Medicine
Sub Category: Hematology
Writer Experience: 20+ Years
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