Description
Title: From Clinical Diagnosis/Treatment, In-Vivo and In-Vitro Investigations, to Patient-Specific Biomechanical Modeling: Mechanics of the Tricuspid Valve
Abstract: The right side of the heart’s unidirectional blood flow depends on the proper operation of the tricuspid valve (TV). Functional tricuspid regurgitation (FTR), in which the valve is unable to stop unintentional backflow of blood from the right ventricle into the right atrium during systole, may result from changes to the tricuspid valvular components, such as the TV annulus. FTR can currently be treated in a number of ways, but research into the tricuspid heart valve, functional tricuspid regurgitation, and the appropriate treatment methodologies is currently limited because cardiac surgeons and cardiologists generally believe that FTR will naturally regress after repair of left-sided heart valve lesions. Recent research has concentrated on I quantifying the biomechanical characteristics of the tricuspid valve apparatus as well as its surrounding heart tissue, (ii) understanding the function of the TV and the onset or progression of FTR using both in-vivo and in-vitro methods, and (iii) computational modeling of the TV to provide new insight into its biomechanical and physiological function. This review paper focuses on these developments and provides an overview of current studies that are pertinent to the TV within the context of FTR. Additionally, this review offers future perspectives and extensions that are vital to advancing our understanding of the tricuspid valve’s functioning and remodeling in both healthy and pathophysiological states.
Keywords: the tricuspid valve; functional tricuspid regurgitation; cardiovascular imaging; mechanical characterization; in-vitro experiments; constitutive modeling; geometrical modeling; finite element modeling; isogeometric analysis (IGA); biaxial mechanical characterization; fluid-structure interactions; material anisotropy; sub-valvular components
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Bioengineering
Writer Experience: 20+ Years
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