Research Paper on From Clinical Diagnosis/Treatment, In-Vivo and In-Vitro Investigations, to Patient-Specific Biomechanical Modeling: Mechanics of the Tricuspid Valve

Description

Title: From Clinical Diagnosis/Treatment, In-Vivo and In-Vitro Investigations, to Patient-Specific Biomechanical Modeling: Mechanics of the Tricuspid Valve

Abstract: The right side of the heart’s unidirectional blood flow depends on the proper operation of the tricuspid valve (TV). Functional tricuspid regurgitation (FTR), in which the valve is unable to stop unintentional backflow of blood from the right ventricle into the right atrium during systole, may result from changes to the tricuspid valvular components, such as the TV annulus. FTR can currently be treated in a number of ways, but research into the tricuspid heart valve, functional tricuspid regurgitation, and the appropriate treatment methodologies is currently limited because cardiac surgeons and cardiologists generally believe that FTR will naturally regress after repair of left-sided heart valve lesions. Recent research has centered on I comprehending the role of the ii) quantifying the biomechanical characteristics of the tricuspid valve apparatus as well as its surrounding heart tissue, and iii) computational modeling of the TV to provide new insight into its biomechanical and physiological function. This review paper focuses on these developments and provides an overview of current studies that are pertinent to the TV within the context of FTR. Additionally, this evaluation offers prospective Perspectives and extensions are essential to improving our understanding of how the tricuspid valve remodels and functions in both healthy and pathophysiological states.

Keywords: the tricuspid valve; functional tricuspid regurgitation; cardiovascular imaging; mechanical characterization; in-vitro experiments; constitutive modeling; geometrical modeling; finite element
modeling; isogeometric analysis (IGA); biaxial mechanical characterization; fluid-structure interactions;
material anisotropy; sub-valvular components

Paper Quality: SCOPUS / Web of Science Level Research Paper

Subject: Bioengineering

Writer Experience: 20+ Years

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