Research Paper on Fluoroquinolone resistance is the focus of a five-year retrospective study of enteric fever in a tertiary care hospital in Kolkata, India, which looked at changing paradigms in antibiotic resistance in Salmonella species.

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Title: Fluoroquinolone resistance is the focus of a five-year retrospective study of enteric fever in a tertiary care hospital in Kolkata, India, which looked at changing paradigms in antibiotic resistance in Salmonella species.

Abstract: Salmonella enterica serovar Typhi and Paratyphi, which are responsible for the multisystem illness enteric fever, present a serious risk in low- and middle-income nations. Between June 2017 and June 2022, a retrospective study was conducted to determine the prevalence and changing trends in antibiotic resistance in Salmonella Typhi and Paratyphi. Patients using the inpatient and outpatient clinics at the School of Tropical Medicine hospital in Kolkata, India provided a total of 4051 blood samples. Blood samples were cultured, and those that were culture positive were processed further for identification using manual and automated methods. The Kirby-Bauer disc diffusion method and VITEK2 were both used to perform an antibiotic susceptibility test (bioMerieux). In total, 45 (1.1%) different Salmonella species were found in the tested samples (n = 4051). The 45 Salmonella isolates were divided into 10 Salmonella Paratyphi A (22.23%) and 35 Salmonella Typhi (77.77%). In the most recent years (2019–2022), we discovered pronounced fluoroquinolone resistance of 100% in both S. Typhi and S. Paratyphi A isolates. One Salmonella Typhi and two Salmonella Paratyphi were discovered. One isolate of Salmonella Paratyphi was multidrug resistant (MDR) and resistant to cefixime, ceftriaxone, ciprofloxacin, and nalidixic acid. In a recent study year (2020), an isolate was discovered that displayed resistance to various antibiotic classes (cephalosporins, fluoroquinolones and carbapenems). In the later years of the study, there was no evidence of third generation cephalosporin resistance. Salmonella isolates that have emerged that are multi-antibiotic resistant present a significant health risk. To better understand Salmonella’s antibiotic susceptibility and resistance pattern against the main classes of antibiotics, additional research is necessary in light of the antimicrobial resistance patterns that were identified in the study.

Keywords: Salmonella; antibiotics; fluoroquinolones; blood culture; public health

Paper Quality: SCOPUS / Web of Science Level Research Paper

Subject: Antibiotics

Writer Experience: 20+ Years

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