Description
Title: Examining the Functions of the Ghrelin Axis in Tumor Growth and Progression in Ghrelin and Cancer
Abstract: The stomach produces and secretes a hormone called ghrelin, which is primarily recognized as an appetite stimulant. It has recently come to light as a potential regulator or biomarker of the development of cancer. It is challenging to interpret this body of literature because the results are inconsistent. In this article, we look for patterns in the connections between ghrelin and different cancers and list key points for further study. Unacylated ghrelin (UAG), acylated ghrelin (AG), the enzyme ghrelin O-acyltransferase (GOAT), and the growth hormone secretagogue receptor are the main participants in the ghrelin family axis (GHSR). Ghrelin is acylated by GOAT, which enables it to bind to the active ghrelin receptor GHSR-1a and start the activation cascade. Ghrelin has splice variants as well, with In1-ghrelin being the most well-known. In this review, we mainly pay attention to In1-ghrelin’s potential as a biomarker for the development of cancer, the distinctive qualities of UAG and AG, the significance of the two known receptor variants GHSR-1a and 1b, and the potential mechanisms by which the ghrelin axis functions. Further research into the ghrelin axis’ function in the proliferation of tumor cells may result in the creation of cutting-edge cancer treatments.
Keywords: cancer; ghrelin; In1-ghrelin; GHSR; tumor
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
Plagiarism Report: Turnitin Plagiarism Report will be less than 10%
Restriction: Only one author may purchase a single paper. The paper will then indicate that it is out of stock.
What will I get after the purchase?
A turnitin plagiarism report of less than 10% in a pdf file and a full research paper in a word document.
In case you have any questions related to this research paper, please feel free to call/ WhatsApp on +919726999915
Reviews
There are no reviews yet.