Research Paper on ER-Mitochondrial Crosstalk: Signaling Beyond (ER) Stress Response and ER Stress-Sensor Proteins

Description

Title: ER-Mitochondrial Crosstalk: Signaling Beyond (ER) Stress Response and ER Stress-Sensor Proteins

Abstract: Unquestionably, current research highlights the significance of interorganellar connections in preserving cellular homeostasis. Each organelle reacts individually or in concert to maintain cellular function under normal physiological circumstances or in the presence of cellular and environmental stress. Mitochondria and the Endoplasmic reticulum (ER) are two significant organelles with highly specialized structural and functional characteristics. Through highly specialized proteins in the region known as the mitochondria-associated ER membrane, these two organelles are physically connected (MAM). This relationship’s molecular basis is intricate and includes many structural and apoptotic proteins in addition to calcium-mediated ion homeostasis. and IRE1alpha The canonical role of PERK is as an ER stress sensor that regulates the unfolded protein response during ER stress. These transmembrane proteins’ presence at the MAM suggests that structure may be involved in biological processes other than ER stress signaling. Recently, there has been a lot of research on the non-canonical use of these sensors. In this review, we will concentrate on the non-canonical function of ER stress sensors beyond ER stress, with a particular emphasis on the ER mitochondrial interdependence.

Keywords: ER stress; endoplasmic reticulum; mitochondria associated membrane (MAM)

Paper Quality: SCOPUS / Web of Science Level Research Paper

Subject: Biomolecules

Writer Experience: 20+ Years

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