Description
Title: Direct-Acting Oral Anticoagulants (DOACs) in the Overweight and Obese: Efficacy and Safety
Abstract: Obesity is crucial to the safety of pharmacologic medications. Although direct oral anticoagulants (DOACs) are more frequently used, there is a dearth of information regarding their use in obese patients. This study’s primary and secondary goals were to evaluate the DOACs’ safety and effectiveness in the treatment of venous thromboembolisms and primary prophylaxis for non-valvular atrial fibrillation (NVAF) in the overweight and obese populations (VTE). In a sizable tertiary care facility, we carried out a retrospective cohort study and collected data by looking through electronic health records. There were no differences in major bleeding (MB) and clinically relevant nonmajor bleeding (CRNMB) rates between normal weight and underweight people and patients with NVAF and VTE who were taking apixaban. The odds of CRNMB for patients with BMI 25 were 5.37 (95% CI 1.50-19.32) times higher than those for patients with BMI 25, according to the multivariate adjusted analysis for rivaroxaban. Furthermore, patients who were taking drugs with known interactions with DOACs had odds of CRNMB that were 6.40 times higher than those who weren’t (95% CI 1.49-27.57), which could not be explained by the combined effects of aspirin and plavix. For both apixaban and rivaroxaban, effectiveness was comparable across all weight groups. These findings confirm that apixaban and rivaroxaban are safe in overweight and obese people and support earlier analyses carried out in the significant phase III trials.
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Medicine
Sub Category: Hematology
Writer Experience: 20+ Years
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