Description
Title: Diabetes-Related Kidney Disease: Glucose- and Non-Glucose-Induced Mitochondrial Dysfunction
Abstract: Diabetes-related kidney disease has a pathogenesis and progression that is significantly influenced by mitochondrial dysfunction (DKD). With a focus on oxidative phosphorylation (OXPHOS), mitochondrial reactive oxygen species (mtROS), biogenesis, fission and fusion, mitophagy, and urinary mitochondrial biomarkers, we will discuss mitochondrial dysfunction seen in both preclinical models of DKD and clinical DKD in this review. The discussion will cover both glucose- and non-glucose-induced mitochondrial dysfunction. The Warburg effect—a metabolic transition from OXPHOS to aerobic glycolysis—occurs in the context of glucose-induced mitochondrial dysfunction, and the resulting toxic intermediates of glucose metabolism contribute to DKD-induced injury. We will discuss the roles of lipotoxicity, hypoxia, and vasoactive pathways, including endothelin-1 (Edn1)/Edn1 receptor type A signaling pathways, in relation to non-glucose-induced mitochondrial dysfunction. The objective of this review is to highlight the complexity of mitochondrial dysfunction in DKD and to discuss how markers of mitochondrial dysfunction could help us stratify patients at risk for DKD, even though the relative contributions of each of these pathways to DKD are still unclear.
Keywords: diabetic kidney disease; mitochondrial dysfunction; mitochondrial reactive oxygen species; Warburg effect
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
Plagiarism Report: Turnitin Plagiarism Report will be less than 10%
Restriction: Only one author may purchase a single paper. The paper will then indicate that it is out of stock.
What will I get after the purchase?
A turnitin plagiarism report of less than 10% in a pdf file and a full research paper in a word document.
In case you have any questions related to this research paper, please feel free to call/ WhatsApp on +919726999915
Reviews
There are no reviews yet.