Description
Title: Current research and upcoming issues regarding pulmonary hypertension in diffuse parenchymal lung diseases
Abstract: One of the most common causes of pulmonary hypertension is lung disease (PH). The progression of lung disease is impacted by the development of PH, which worsens the clinical symptoms and prognosis. The most recent publications state that in patients with a genetic predisposition, PH in the course of lung diseases develops as a result of both “parenchymal” and vascular pathology. Prolonged infection, especially one that is viral, may act as an additional motivator. The only scientific way to diagnose PH is through right heart catheterization (RHC), an invasive procedure. The most recent recommendations state that RHC and the results of pulmonary function tests should form the basis of the management algorithm for PH and coexisting interstitial lung disease. The majority of patients with advanced lung disease experience mild PH. In this group, the best management of the underlying lung pathology in conjunction with long-term oxygen therapy is advised. The alternate cause of PH must be looked for in cases of severe PH (mean resting pulmonary artery pressure (mPAP) 35 mm Hg). Patients with severe PH taking part in clinical trials should be the only ones who can take PAH-specific medications. This review discusses recent randomized clinical trials with PAH-specific medications in patients with diffuse parenchymal lung diseases as well as the value of various non-invasive techniques (echocardiography, radiological examination, exercise capacity, and brain natriuretic peptides assessment) in the process of screening for PH.
Keywords: pulmonary hypertension, idiopathic pulmonary fibrosis, diffuse parenchymal lung diseases, diagnosis, treatment
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Advances in Respiratory Medicine
Writer Experience: 20+ Years
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