Research Paper on Controlling Arteriogenesis and Mast Cells Is Essential to Bioengineering Approaches for Critical Allograft-Based Bone Defect Repair

Description

Title: Controlling Arteriogenesis and Mast Cells Is Essential to Bioengineering Approaches for Critical Allograft-Based Bone Defect Repair

Abstract: Even though the majority of fractures recover, serious defects in the bone do not, as a result of mesenchymal stem cells’ aberrant differentiation toward fibrosis rather than osteogenesis. Recent studies have shown that fibrotic non-unions are associated with arteriogenesis in the center of the defect and accumulation of mast cells around large blood vessels. While conventional bioengineering solutions to this problem have focused on enhancing angiogenesis, which is necessary for bone formation, recent studies have shown that this is not the case. Due to the inhibition of arteriogenesis and mast cell numbers within the healing bone, recombinant parathyroid hormone (rPTH; teriparatide; Forteo) therapy has recently shown to have anti-fibrotic effects on non-unions and critical bone defects. This work reviews the current state of the field and offers insights on how teriparatide therapy could be used as an adjuvant for healing crucial bone defects because this new direction holds great promise for a solution to significant clinical challenges in craniofacial reconstruction and limb salvage procedures. Last but not least, because teriparatide therapy is contraindicated in the presence of cancer, which accounts for a sizable portion of these patients, we describe preliminary research on adjuvant therapies that may show promise in the future by directly inhibiting arteriogenesis and mast cell accumulation at the defect site.

Keywords: critical bone defect; arteriogenesis; osteogenesis; fibrosis; mast cells; recombinant parathyroid hormone (rPTH; teriparatide; Forteo)

Paper Quality: SCOPUS / Web of Science Level Research Paper

Subject: Bioengineering

Writer Experience: 20+ Years

Plagiarism Report: Turnitin Plagiarism Report will be less than 10%

Restriction: Only one author may purchase a single paper. The paper will then indicate that it is out of stock.

What will I get after the purchase?

A turnitin plagiarism report of less than 10% in a pdf file and a full research paper in a word document.

In case you have any questions related to this research paper, please feel free to call/ WhatsApp on +919726999915