Description
Title: Comprehensive information on the rare condition known as pulmonary blastoma
Abstract: Introduction: Less than 0.5% of primary lung tumors are pulmonary blastomas, a malignancy that is extremely uncommon. It is a member of the pulmonary sarcomatoid carcinoma family and is frequently distinguished by a biphasic pattern with both mesenchymal and epithelial components. Only a small number of cases have been documented globally. The purpose of this study is to review and evaluate the pulmonary blastoma literature. Materials and techniques Using variations of the keywords “pulmonary blastoma,” “biphasic pulmonary blastoma,” and “sarcomatoid carcinoma,” a narrative literature review of the PubMed database from the database’s inception up to January 2021 was conducted. Results: The malignant mesenchymal and epithelial components of pulmonary blastoma are present. The pathogenesis of the biphasic cell population’s origin is still a mystery. Typical immunohistochemical stains are helpful in confirming the diagnosis. 40% of cases are asymptomatic, and the clinical symptomatology is non-specific. Compared to other types of lung cancer, it is diagnosed at a younger age and is frequently not metastatic at the time of diagnosis, allowing for surgical treatment. Data on survival and management are rare and typically drawn from lone cases. Targeted therapy developments could open up new treatment possibilities. Given the rarity of the cases, multicenter cooperation is required to develop treatment recommendations.
Keywords: pulmonary blastoma, sarcomatoid lung carcinoma, biphasic pulmonary blastoma
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Advances in Respiratory Medicine
Writer Experience: 20+ Years
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