Research Paper on Colon and Rectum Macro- and Micro-Mechanics II: Theoretical and Computational Approaches

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Title: Colon and Rectum Macro- and Micro-Mechanics II: Theoretical and Computational Approaches

Abstract: A variety of gastrointestinal diseases, such as diverticulosis, diverticulitis, anorectal disorders, ileus, and chronic constipation, are linked to abnormal colorectal biomechanics and mechanotransduction. Visceral pain, which is primarily brought on by mechanical distension, has a special biomechanical component that is essential for mechanotransduction, the process by which sensory afferents encode mechanical stimuli in the colorectum. Focused study of the macro- and micro-mechanics of colon tissue is necessary to fully comprehend the underlying mechanisms of visceral mechanical neural encoding. Growing efforts are being made to create constitutive frameworks to understand and predict the anisotropic and nonlinear biomechanical behaviors of the multilayered colorectum, which are motivated by biomechanical experiments on the colon and rectum. We will summarize our most recent developments in these fields after reviewing the literature on the computational modeling of the colon and rectum, stretch-sensitive afferent endings, and mechanical neural encoding. Current models shed light on the biomechanics at the organ and tissue levels as well as the stretch-sensitive afferent endings of colorectal tissues, but modeling theory still faces significant obstacles. To establish a coherent multiscale framework for projecting mechanotransduction from organ-level biomechanics, the research community has not linked the biomechanical models to those of mechanosensitive nerve endings.

Keywords: colorectum; biomechanics; afferent endings; mechanotransduction; constitutive modeling; theoretical and computational models

Paper Quality: SCOPUS / Web of Science Level Research Paper

Subject: Bioengineering

Writer Experience: 20+ Years

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