Description
Title: Challenges and Opportunities of DNA Methylation in Regulatory T Cell Differentiation and Function
Abstract: DNA methylation is a legitimate epigenetic marker that has been connected to regulatory T (Treg) cell differentiation and function. Treg cells are a subset of CD4 T cells that are crucial for preserving immune homeostasis and controlling autoimmunity and the antitumor immune response. Dynamic regulation of DNA methylation includes de novo methylation, passive and active demethylation, and maintenance of preexisting patterns. According to sporadic evidence, these processes regulate a variety of Treg cell lifespan processes, including transdifferentiation, effector T cell and innate immune cell suppression, cell fate maintenance, and lineage induction. Despite significant advancements, it is still unknown how differential DNA methylation affects the immunological function and fate of Treg cells. In this article, we review recent developments and discuss the issues that still need to be resolved in order to fully comprehend the immunological functions and mechanisms that dynamic DNA methylation plays in regulating Treg cell differentiation and function. We also investigate the potential for targeting DNA methylation in these processes to therapeutically manipulate the suppressive function of Treg cells.
Keywords: DNA methylation; epigenetics; regulatory T cells; DNMT1; DNMT3A; DNMT3B; TET1;TET2; TET3; Foxp3
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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