Description
Title: Cell Therapeutic Preparations for Restoring Volumetric Muscle Loss
Abstract: Volumetric muscle loss (VML) causes extensive damage to skeletal muscle tissue that is beyond the body’s natural ability to repair itself, leading to functional impairment that is permanent. Native muscle function cannot be fully restored by current clinical therapies. Cell-based therapies have recently come to light as a promising strategy to encourage the regeneration of skeletal muscle after injury or illness. Muscle differentiation has been demonstrated in some stem cell populations, including muscle stem cells, mesenchymal stem cells, and induced pluripotent stem cells (iPSCs). Support cells, including endothelial, nervous, and immune cells, are essential for modulating the processes of inflammation, angiogenesis, and innervation as well as providing paracrine signaling cues for myogenesis. Cell therapies must be given the right intercellular signals and instructive microenvironmental cues in order to be effective. With an emphasis on preclinical testing and upcoming developments in the field, this review discusses the most recent advancements in cell-based therapies for the treatment of VML.
Keywords: tissue engineering; cell transplantation; stem cells; satellite cells; induced pluripotent stem cells; volumetric muscle loss
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Bioengineering
Writer Experience: 20+ Years
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