Description
Title: Cardiovascular safety of the fixed-dose combination of the bronchodilators indacaterol and glycopyrronium
Abstract: Patients with COPD who have failed prior monotherapy with one of these medications should receive combination therapy with anticholinergics and b2-agonists. The effectiveness of medications taken separately can be increased by the combined effects of the two bronchodilation mechanisms. Although the effectiveness of the LABA and LAMA combination has already been established, there is still uncertainty regarding the safety profile of this therapy, particularly with regard to the cardiovascular system. The overall safety profile of the combined preparation in comparison to placebo and the active comparators, particularly the cardiovascular safety of the fixed-dose formulation, is discussed in the paper. A combination of two ultra-long-acting bronchodilators with different complementary mechanisms of action has been shown to increase the effectiveness of COPD therapy without compromising safety, according to the data.
Keywords: combination therapy, indacaterol, glycopyrronium, cardiovascular safety
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Advances in Respiratory Medicine
Writer Experience: 20+ Years
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