Description
Title: Cardiac Glycosides’ Potential Drug Development: Present and Future Aspects for Cancer Therapeutics
Abstract: Natural sterols known as cardiac glycosides are a class of secondary metabolites that have been isolated from both plants and animals. Since they can speed up cardiac contractions by acting on the cellular sodium potassium ATPase pump, these cardiotonic agents are well known and accepted in the treatment of various cardiac diseases. However, a growing number of recent initiatives have been concentrated on investigating these compounds’ antitumor and antiviral potential. Numerous studies have suggested that cardiac glycosides (CG) have antitumor properties, making them the most diverse naturally derived compounds that are highly advised for the treatment of various cancers. Transcriptional regulators that are mutated or dysregulated have also attained prominence as potential therapeutic targets. In order to highlight potential therapeutic targets in cancer management, we have investigated the most recent developments in CGs-mediated cancer scope and taken into account a number of signaling pathways, molecular aberrations, transcription factors (TFs), and oncogenic genes.
Keywords: cardiac glycosides; transcription factors; therapeutic target; cancer therapy; in vitro and in vivo anticancer activities
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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