Description
Title: Cancer Im Add Formmune Checkpoint Inhibitor Therapy Using Phytochemicals
Abstract: By preventing T cells from recognizing tumor cells, the interaction of immune checkpoint molecules in the tumor microenvironment inhibits the anti-tumor immune response. A promising therapeutic option for the treatment of cancer is emerging: immune checkpoint inhibitor (ICI) therapy. However, there are still challenges with using ICIs to modulate the immune system, including serious immunogenic side effects and a lack of response against many cancer types. Natural substances derived from plants offer control over different signaling cascades and have been used to treat many diseases, including cancer. Increasing evidence suggests that phytochemicals may be effective when combined with other ICI therapeutic agents for modulating immune checkpoint-related signaling molecules. In vitro or in vivo models of various cancers have recently been reported to demonstrate the modulatory effects of phytochemicals on immune checkpoints. Immune checkpoints that are druggable and the factors that control them are outlined in this review. Additionally, phytochemicals that can inhibit PD-1/PD-L1 binding, the most extensively researched target of ICI therapy, were thoroughly reviewed and categorized based on chemical structure subgroups. It might contribute to the expansion of research on phytochemicals as potential combinational adjuvants. Future clinical trials could confirm the synergistic effects of ICI therapy and phytochemicals that have been studied in preclinical settings.
Keywords: phytochemical; immune checkpoint; PD-1; PD-L1; cancer immunotherapy
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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