Description
Title: Biomaterials’ Mineralization for Bone Tissue Engineering
Abstract: Comparing mineralized biomaterials to their non-mineralized counterparts, it has been shown that the former improve bone regeneration. Because mineralized scaffolds perform better than non-mineralized ones Scaffolds are promising techniques for the development of functional, biomimetic bone because of their mechanical and surface properties, osteoconductivity and osteoinductivity, and mineralization strategies. scaffolds. A particularly promising method for guided bone regeneration is the mineralization of three-dimensional (3D) scaffolds. We review the main techniques for mineralizing tissue engineering constructs in this paper. The resulting scaffolds offer carbonated apatite, Ca5(PO4,CO3)3, a mineral that is chemically similar to the inorganic component of natural bone (OH). Additionally, we go over the methods used to describe the mineralized scaffolds, including their degree of mineralization, surface features, mechanical characteristics, and chemical make-up of the minerals that were deposited. Studies in in vitro cell culture demonstrate the mineralized scaffolds’ strong osteoinductive properties. We also provide an overview of 3D mineralized construct applications and the justification for their use, based on examples from the literature. Due to their superior mechanical qualities and capacity for cell recruitment, mineralized scaffolds have shown to improve bone regeneration in animal models, making them a better choice for bone tissue engineering than non-mineralized scaffolds.
Keywords: bone; tissue engineering; mineralization; biomaterial; scaffold
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Bioengineering
Writer Experience: 20+ Years
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