Description
Title: Biological Importance and Synthesis of 2-(thio)ureabenzothiazoles
Abstract: It has been demonstrated that the (thio)urea and benzothiazole (BT) derivatives have a variety of biological activities. The 2-(thio)ureabenzothizoles (TBT and UBT) that are created when these groups bond may have favorable physicochemical and biological properties. Compounds of great significance in medicinal chemistry include UBTs and TBTs. For instance, the UBT derivative frentizole is used to treat systemic lupus erythematosus and rheumatoid arthritis. Commercial fungicides UBTs Bentaluron and Bethabenthiazuron are used as herbicides and wood preservatives in winter corn crops. We created this bibliography review based on these premises, which covers the chemical properties of UBTs and TBTs as potential therapeutic agents as well as studies on the mechanisms underlying a range of pharmacological activities. This work spans synthetic methodologies from 1935 to the present, highlighting the most recent methods for obtaining UBTs and TBTs with various substituents as shown in 42 schemes and 13 figures, and it is concluded with 187 references. This fascinating review is also focused on the chemical interactions between 1,10-(thio)carbonyldiimidazoles [(T)CDI]s, (thio)carbamoyl chlorides, carbon disulfide, iso(thio)cyanates, and 2-aminobenzothiazoles (2ABTs). For medicinal chemists working on the design and synthesis of this class of compounds, this topic will offer information that will be useful for suggesting new pharmacophores and testing the compounds’ biological activities.
Keywords: 2-aminobenzothiazoles; (thio)ureabenzothiazoles; (thio)phosgene; iso(thio)cyanates; thio)carbonyldiimidazoles; carbamoyl chlorides; carbon disulfide
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Chemistry
Writer Experience: 20+ Years
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