Description
Title: Bacteria and microalgae Omics for Bioprospecting and Drug Discovery
Abstract: “Omics” refers to a combinatorial method of high-throughput biological entity analysis for a variety of purposes. Genomics, transcriptomics, proteomics, lipidomics, and metabolomics are all included in it. A wide range of genetic, biochemical, and consequently physiological variations are displayed by bacteria and microalgae as a result of their exposure to biotic and abiotic dynamics in their ecosystem conditions. As a result, ideal circumstances for sufficient growth and production of beneficial bacterial or microalgal metabolites are highly unpredictable. The bioprospecting process is laborious, taxing, and expensive using traditional methods, which use microbe isolation and “blind” culture optimization along with numerous chemical analyses. NGS technology advancements have provided a platform for the pan-genomic analysis of microbes from the community and strain level downstream to the gene level. Variations in gene expression, epigenetic regulation, and subsequent biochemical profiles define an organism’s inborn metabolic repertoire in response to changing environmental factors in both nature and the lab. We may be able to learn more about the molecular and biochemical characteristics of the research microbes through proteome and metabolome analysis. The genomes, genes involved in the secondary metabolite biosynthetic pathway, transcriptomes, and metabolomes of bacteria and microalgae were the main topics of this review, which gives an overview of recent studies that used omics as a reliable, all-encompassing method for screening bacteria and microalgae to tap into their potential as sources of drug leads. We also point out how recent research has combined analytical chemistry and molecular biology techniques, which emphasizes the need for advancements in bioinformatics and chemoinformatics as crucial tools in the discovery of novel bacterial and microalgal strains as well as new drug leads.
Keywords: omics; drug discovery; bacteria; microalgae; biosynthetic gene clusters
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Antibiotics
Writer Experience: 20+ Years
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