Description
Title: Application of Endogenous and Exogenous Mesenchymal Progenitor Cells in the Regeneration and Repair of Skeletal Tissue
Abstract: An approach that is currently under study involves using adult mesenchymal stem/progenitor cells to promote skeletal tissue repair. Even though researchers are constantly coming up with innovative and thoughtful approaches to using these cells for tissue repair, the vast majority of these techniques can ultimately be Two main strategies can be distinguished: (1) promoting the migration of endogenous host cells to the injury site; and (2) physically introducing exogenous cells into the injury site, either by autologous or allogeneic implantation. The purpose of this paper is to conduct a thorough review of recent key literature on the application of these two techniques to promote healing and repair of various skeletal tissues. As to be expected, each of the two approaches has its own benefits and drawbacks (which we outline), particularly when taking into account the various microenvironments of various skeletal tissues like bone, tendon, and ligament, as well as cartilage and fibrocartilage. This article lists ongoing clinical trials that have resulted from the use of these cells and techniques, as well as stem/progenitor cells that are frequently used for repairing various skeletal tissues. Finally, we talk about where we believe the field is headed in the coming years.
Keywords: skeletal tissue repair; regeneration; stem cell; progenitor cell; bone; cartilage; fibrocartilage; tendon; ligament
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Bioengineering
Writer Experience: 20+ Years
Plagiarism Report: Turnitin Plagiarism Report will be less than 10%
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