Research Paper on An in vitro study found that plant extracts had a synergistic effect on endodontic pathogens isolated from teeth with failed root canal treatments.

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Title: An in vitro study found that plant extracts had a synergistic effect on endodontic pathogens isolated from teeth with failed root canal treatments.

Abstract: Background and goals: The purpose of this study was to assess the synergistic antimicrobial activity of extracts from Salvadora persica (Miswak), Commiphora molmol (myrrh), and Azadirachta indica (neem) in combination with commercially available antimicrobial agents, such as penicillin, tetracycline, ofloxacin, and fluconazole, on endodontic pathogens like Enterococcus f Materials and Procedures Using sterile paper points that were left in the root canals of the teeth undergoing retreatment for 30 seconds, microbiological samples were taken. By measuring the diameter of the inhibition zones, the disc diffusion method was used to test the susceptibility of microbes to plant extracts and antimicrobials. The minimum bactericidal concentration (MBC) and minimum fungicidal concentration (MFC) of the plant extracts were evaluated in relation to the microbes. The synergistic effect of plant extracts combined with antibiotics against the resistant endodontic microbes was estimated using the fractional inhibitory concentration index (FICI). Results: All three plant extracts—Commiphora molmol, Azadirachta indica, and Salvadora persica—were found to be effective against the pathogenic microorganisms used in the experiments, with the exception of Candida albicans, which Azadirachta indica and Salvadora persica failed to kill. Azadirachta indica demonstrated the highest antimicrobial activity against Enterococcus faecalis (MIC = 0.09 1.2 mg/mL, MBC = 0.78 1.25 mg/mL), while Commiphora molmol demonstrated the lowest antimicrobial activity against Actinomyces naeslundii (MIC = 12.5 3.25 mg/mL, MBC = 100 3.75 mg/mL). Fluconazole and Commiphora molmol had the best synergy against Candida albicans (FICI = 0.45). Conclusions: The current study outlines the variable antimicrobial activity of plant extracts against the pathogenic microorganisms used in experimental endodontic procedures. An important tool in the fight against relative resistant endodontic microorganisms that have become a source of concern in recent years and can cause failure even in treatment procedures that follow all necessary protocols is the use of lant extracts in combination with different antimicrobials.

Keywords: endodontic pathogens; synergy; plant extracts; root canal treatment failure; antimicro-bial activity

Paper Quality: SCOPUS / Web of Science Level Research Paper

Subject: Antibiotics

Writer Experience: 20+ Years

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