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Subject: Bioengineering
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Title: Allyl Isothiocyanate’s Anticancer Activity, Mechanism, and Delivery
Abstract: The cruciferous vegetables of the Brassicaceae family, such as cabbage, broccoli, mustard, wasabi, and cauliflower, are rich sources of the phytochemical allyl isothiocyanate (AITC). These vegetables’ strong flavor is primarily brought on by the presence of AITC in them. In the plant, AITC is physically separated from myrosin cells that contain myrosinase and is instead stored as sinigrin, a type of glucosinolate. Myrosinase is released upon tissue disruption and hydrolyzes sinigrin to produce AITC and by-products. In spite of being irritating and toxic, AITC is an organosulfur compound with pharmacological properties such as anticancer, antibacterial, antifungal, and anti-inflammatory actions. Despite AITC’s potentially effective anticancer properties, its clinical application still faces difficulties because of a number of factors, including its low aqueous solubility, instability, and low bioavailability. The anticancer activity of AITC against various cancer models is compiled from the literature in this review. There are a number of pathways that have been found, and these are discussed in this review, despite the fact that the mechanism of action is still not fully understood. The delivery of AITC has not received much attention, which hinders its clinical application. However, attention is given to the few studies that have shown how nanotechnology can be used to speed up the delivery of AITC.
Keywords: allyl isothiocyanate; sinigrin; myrosinase; glucosinolate; anticancer; mechanism of action;drug delivery
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Bioengineering
Writer Experience: 20+ Years
Plagiarism Report: Turnitin Plagiarism Report will be less than 10%
Restriction: Only one author may purchase a single paper. The paper will then indicate that it is out of stock.
What will I get after the purchase?
A turnitin plagiarism report of less than 10% in a pdf file and a full research paper in a word document.
In case you have any questions related to this research paper, please feel free to call/ WhatsApp on +919726999915
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