Description
Title: Aging Skeletal Muscle: Advanced Glycation End-Products
Abstract: Skeletal muscle experiences harmful changes as it ages, including muscle atrophy, a switch from fast to slow muscle fibers, and an increase in collagen content, which leads to sarcopenia, an age-dependent disease that results in muscle wasting. In old age, the Maillard reaction causes advanced glycation end-products (AGEs) to non-enzymatically accumulate on the muscular collagens, promoting the buildup of intramuscular collagen and stiffening the microenvironment. crossing-over of collagen. This review explains how the motor nerve contributes to the aging of the skeletal muscle extracellular matrix (ECM), focusing on the role of collagen and AGE cross-linking. Future research directions are also discussed in detail, with the highlighted understudied role of AGEs in skeletal muscle aging. Despite more than 50 years of research, the relationship between intramuscular collagen cross-linking and aggregation in sarcopenia is still poorly understood in relation to the effects of AGE on muscle physiology. It is also suggested that intramuscular cross-linking and muscular AGE levels may be affected by motor nerve aging.
Keywords: skeletal muscle aging; sarcopenia; advanced glycation end-products; collagen; collagen cross-linking; motor nerve
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Bioengineering
Writer Experience: 20+ Years
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