Description
Title: A Retrospective Cohort Study on Fluoroquinolone Adverse Effects in a South Indian Tertiary Healthcare Facility
Abstract: According to the Food and Drug Administration’s (FDA) safety review, the use of fluoroquinolones (FQs) is associated with serious adverse effects that can be permanently disabling. The human body’s tendons, muscles, joints, nerves, and central nervous system are all compromised by these negative effects. The study’s goal was to compare the use of FQs and other antibiotics to determine the frequency and risk factors for adverse drug reactions (ADRs). At the Kasturba Medical College Hospital in Manipal, India, a retrospective cohort study was carried out over a period of seven months. The study cohort (SC; n = 482) of patients was chosen, while the reference cohort (RC; n = 318) consisted of those who were not prescribed FQs. According to the findings, 4.1% (13) patients in the RC and 8.5% (41) of patients in the SC experienced ADR development. A similar number of ADRs were seen when administered via parenteral and oral routes. The most adverse drug reactions (ADRs) were caused by levofloxacin, particularly with the 750-mg dose. According to a multiple logistic regression model, FQ use and concurrent steroid use were found to be independent risk factors for the development of ADRs in antibiotic users (OR: 2.27; 95% CI: 1.18-4.39; p = 0.015; 3.19; 1.31-7.79; p = 0.011); however, age was found to be protective (OR: 0.98; 95% CI: 0.97-1.00; p = 0.047). The study discovered that FQs had a higher incidence of ADRs than other antibiotics. According to the study, there is a negative correlation between the use of FQ and the emergence of ADRs. FQs are also less safe than other antibiotics. FQs should only be used in situations where there are no other options available.
Keywords: adverse effects; drug safety; FDA; fluoroquinolones
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Antibiotics
Writer Experience: 20+ Years
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