Description
Title: A Report from Eastern India on Red Cell Alloimmunization and Autoimmunity in Thalassemia Patients
Abstract: Introduction. In thalassemic patients who depend on blood transfusions, red blood cell (RBC) alloimmunization and autoimmunization continue to be serious issues. As pretransfusion antibody screening is not frequently carried out, there are few data on the incidence of RBC alloimmunization and autoimmunization in thalassemic patients from the eastern part of India. Aims. to evaluate the prevalence of RBC autoimmunization and alloimmunization in patients with thalassemic who depend on transfusions in eastern India. Materials and procedures 500 thalassemia cases in all were examined. Using commercially available panel cells (Diapanel, Bio-rad, Switzerland), the column agglutination method was used to screen for and identify antibodies. Using polyspecific Coombs (IgG + C3d) gel cards, autocontrol and direct antiglobulin tests were performed on all patients to identify autoantibodies. Results. 28 patients overall (5.6%) developed RBC alloimmunization, and 5 patients (1%), had autoantibodies. The most frequent alloantibody was against c (28.57%), followed by E (21.42%). Five of the 28 patients (17.85%) had antibodies against both c and E development. Conclusion. The results of this study show that the rates of RBC auto- and alloantibody development are significant in our area. To ensure safe transfusion procedures, pretransfusion antibody screening must therefore be started in eastern India.
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Medicine
Sub Category: Hematology
Writer Experience: 20+ Years
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