Research Paper on A Pilot Study of Safety, Efficacy, and Cost-Effectiveness of Decitabine Compared with Low-Dose Cytarabine for the Treatment of Older Patients with Newly Diagnosed Acute Myeloid Leukemia

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Title: A Pilot Study of Safety, Efficacy, and Cost-Effectiveness of Decitabine Compared with Low-Dose Cytarabine for the Treatment of Older Patients with Newly Diagnosed Acute Myeloid Leukemia

Abstract: Introduction. Acute Myeloid Leukemia (AML) is more common as people age, and it can be difficult to treat. In order to compare decitabine’s safety, efficacy, and cost-effectiveness with those of cytarabine in older AML patients who are not suitable for intensive chemotherapy, this prospective case control study was conducted. Materials and procedures Decitabine or cytarabine was given to 30 eligible patients with newly diagnosed AML who were older than 60. Overall survival was the main goal (OS). Comparing adverse events and the cost-effectiveness of therapy in the two study groups was the secondary goal. Results. In this study, decitabine and cytarabine were given to 15 patients each. The median OS for each treatment group was 5.5 months. The treatment groups’ hazard ratio was 0.811, with a 95% confidence interval of 0.390 to 1.687. Both groups’ toxicity profiles were comparable. Decitabine had a chemotherapy cycle cost of 24,200 INR, whereas low-dose cytarabine had a cost of 1,600 INR. For the decitabine group, the median simplified cost-effectiveness ratio was 0.00022, and for the low-dose cytarabine group, it was 0.0034. Conclusions. Decitabine and low-dose cytarabine should be chosen for elderly AML patients based on preference and cost. Both of these agents have comparable OS and toxicity, according to our study. In developing nations, low-dose cytarabine outperforms decitabine because it is more affordable.

Paper Quality: SCOPUS / Web of Science Level Research Paper

Subject: Medicine

Sub Category: Hematology

Writer Experience: 20+ Years

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