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Title: A Particular Risk Factor for Rituximab Infusion-Related Reactions in CD20-Positive B-Cell Non-Hodgkin Lymphoma Is Bone Marrow Infiltration
Abstract: Background. Patients with CD20-positive B-cell non-Hodgkin lymphoma may be at risk for infusion-related reactions (IRRs) due to lymphoma cells infiltrating their bone marrow (B-NHL). The impact of B-NHL cell infiltration in the bone marrow on the incidence rate of grade 2 or higher IRRs with the administration of rituximab has been retrospectively studied in this paper, despite the lack of sufficient data. Methods. In this study, participants with B-NHL that was CD20-positive and receiving rituximab induction therapy for the first time were included. May-Giemsa staining of bone marrow films and flow cytometry analysis of bone marrow aspiration samples were carried out to assess the B-NHL cell infiltration of the bone marrow. The Common Terminology Criteria for Adverse Events version 4.0’s IRR criteria were used to calculate the IRR grade. Results. 127 patients in total were qualified for this study. In 43 (34%) of the patients, IRRs of grade 2 or higher were noted. Use of glucocorticoids prior to rituximab infusion was found to be a significant risk-reducing factor for grade 2 or higher IRRs in univariate analysis. Regardless of glucocorticoid premedication, advanced disease stages (Ann Arbor: stages III and IV) or bone marrow infiltration of B-NHL cells revealed the risk factors. In patients who had never taken glucocorticoids before, bone marrow infiltration was discovered to be a separate risk factor using multivariate analysis. Conclusion. A risk factor for grade 2 or higher IRRs at the first round of rituximab induction therapy without glucocorticoid premedication is the presence of B-NHL cells infiltrating the bone marrow.
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Medicine
Sub Category: Hematology
Writer Experience: 20+ Years
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