Description
Title: 3D Cardiac Constructs from Human Induced Pluripotent Stem Cells Using Bioengineering Techniques
Abstract: The body’s various cell types can be created using human induced pluripotent stem cells (hiPSCs). Consequently, hiPSC-derived cardiomyocytes (hiPSC-CMs) are an important cell type. source for regenerative medicine, drug testing, and disease modeling. Applications for hiPSC-CMs are constrained by their infancy in two-dimensional (2D) culture. Cardiac tissue engineering offers fresh hope for both fundamental and applied research. Advanced bioengineered cardiac in vitro models have the capacity to produce contractile structures that serve as exquisite in vitro heart microtissues for drug testing and disease modeling, promoting the discovery of more effective treatments for cardiovascular diseases. disorders. We will introduce recent developments in bioengineering technologies to create in vitro cardiac tissues from hiPSCs in this review.
Keywords: 3D bioprinting; 3D models; cardiac organoid; cardiac tissue engineering; cardiomyocytes; CPVT; differentiation; disease modeling; drug development; drug screening; ECM; heart-on-a-chip; hiPSC-CMs; human induced pluripotent stem cell; iPSC; Layer-by-Layer; maturation
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Bioengineering
Writer Experience: 20+ Years
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