Description
Title: The Complete Guide to Extracellular Heat Shock Protein-90 (eHsp90)
Abstract: Heat Shock Protein-90 (Hsp90), which was first identified as being “extracellular,” wasn’t formally acknowledged until 2008 at the 4th International Conference on The Hsp90 Chaperone Machine (Monastery Seeon, Germany). Studies discussed at the conference under the heading “extracellular Hsp90 (eHsp90)” offered concrete proof of eHsp90’s function in skin wound healing and cancer invasion. In vitro and in vivo studies have been conducted over the past 15 years using wound healing, tissue fibrosis, and tumor models to examine the secretion, action, biological function, therapeutic targeting, preclinical evaluations, and clinical utility of eHsp90. A crucial stress-responding molecule that targets all of the pathophysiological conditions is eHsp90. Despite the studies, we still know very little beyond speculation about a number of important issues. Does eHsp90 actually come from intentionally secreting live cells, or does it instead come from accidentally leaking dead cells? Why did evolution develop an intracellular chaperone with reported extracellular duties that could (easily) be carried out by conventional secreted molecules but also serves as a secreted factor? Is eHsp90 a better drug target with regard to safety and efficacy than intracellular Hsp90 chaperone? In this review, we sum up what we know about eHsp90, present our conceptual interpretations of the data, and offer suggestions for eHsp90 research that will be clinically relevant in the future.
Keywords: extracellular Hsp90; stress; mechanism of action; wound healing and cancer
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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