Description
Title: Targeted Immunotherapy Nanoparticles for Alzheimer’s Disease: A Comparison of Tau and Amyloid
Abstract: Alzheimer’s disease (AD), which is characterized by the accu-mulation of amyloid- plaques and intracellular neurofibrillary tangles in the brain along with a high acetylcholinesterase activity, is a rapidly expanding global concern. When patients have experienced extensive neuronal death and irreparable brain damage, AD diagnosis is typically made too late. The tau hypothesis and the amyloid- hypothesis are the two main hypotheses of AD that have given rise to a number of therapeutic targets. In this article, we’ll look into and contrast various AD treatment options, focusing primarily on nanoparticles (NPs) that are directed at the brain and pathological signs of the condition. We looked at preclinical studies that used targeted nanocarriers against tau, amyloid-beta, or both to successfully increase drug bioavailability in the brain. Then, in order to determine which protein is more effective at therapeutic targeting, we compared these trials. We discovered that the amyloid-hypothesis was the main foundation for the search for a cure, with A dysplasia emerging as the most validated and compelling therapeutic target. In animal models, targeted NPs have been shown to improve the bioavailability and efficacy of AD therapies. The successful application of targeted NPs for combination therapies will benefit from a better understanding of AD mechanisms.
Keywords: Alzheimer’s disease (AD); nanoparticles (NPs); blood–brain barrier (BBB); drug delivery; targeted medicine; neurodegeneration
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
Plagiarism Report: Turnitin Plagiarism Report will be less than 10%
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