Description
Title: Potential Roles of Major NAD+-Dependent Enzymes and Plant-Derived Natural Products in Cisplatin-Induced Kidney Toxicity
Abstract: A common anti-cancer medication with FDA approval for the treatment of various solid tumors is called cisplatin. However, cisplatin’s medical and clinical uses are constrained by its severe side effects, particularly kidney toxicity. This brief review discusses the main mechanisms of cisplatin-induced renal toxicity, which include oxidative stress, inflammation, and renal fibrosis. We focus on the underlying mechanisms of cisplatin-induced kidney damage in relation to NAD+-dependent redox enzymes like mitochondrial complex I, NAD kinase, CD38, sirtuins, poly-ADP ribosylase polymerase, and nicotinamide nucleotide transhydrogenase (NNT), as well as their potential roles in the amelioration of cisplatin-induced kidney damage provided by natural We also go over general techniques used to develop mouse and rat models of cisplatin-induced kidney damage. We draw attention to the fact that additional research, along with intensive study of NAD+ redox biology and the protective effects of natural products against cisplatin-induced kidney injury, will be required to analyze the function of each NAD+ -dependent redox enzyme and its involvement in modulating cisplatin-induced kidney injury.
Keywords: cisplatin; kidney toxicity; redox imbalance; mitochondria; natural products; oxidative stress
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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