Description
Title: Regulation of SOCE in ER-PM Junctions by STIM Proteins
Abstract: Endoplasmic reticulum (ER) and plasma membrane (PM) are positioned in close proximity to one another to form ER-PM junctions, which are membrane contact sites. The constitutive and dynamic enrichment of proteins, which either support junctional stability or regulate the lipid levels of both ER and plasma membranes, is necessary for the formation and stability of these junctions. Due to their role as assembly hubs for Ca2+ signaling complexes, ER-PM junctions have attracted a lot of attention lately. This review highlights: (1) key findings underlying STIM protein accumulation in ER-PM junctions; (2) modulation of Orai/STIM complexes by other junctional components; and (3) the coordination and coupling of Orai1 channel activation with downstream signaling pathways.
Keywords: ER-PM junctions; STIM; Orai1; phospholipids; calcium signaling; SOCE
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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