Description
Title: The role of sarcomeric gene variants in the background of coronary artery disease and their relationship to left ventricular dysfunction
Abstract: One of the main causes of death in developing nations is cardiovascular disease, which typically begins as hypertension or coronary artery disease (CAD). Many CAD patients experience left ventricle dysfunction in later stages (LVD). The primary prognostic factor in CAD patients is left ventricular ejection fraction (LVEF). The left ventricle of the heart loses its functional capacity as a result of the complex multifactorial condition known as LVD. Numerous genetic studies have linked dilated cardiomyopathy and LVD (DCM). Significant progress has been made in recent years in determining the genetic underpinnings of cardiac diseases, which has furthered our understanding of the underlying molecular mechanisms of each disease. The likelihood of establishing a particular genetic diagnosis has increased as a result of this development, opening up new opportunities for practitioners, patients, and families to make use of this genetic information. Cardiomyopathies have been linked to numerous sarcomeric gene mutations. The role of the sarcomeric genes in LVD, a major contributor to cardiac failure and a leading cause of heart failure, will be discussed in this review.
Keywords: sarcomere; dilated cardiomyopathy; left ventricle dysfunction; actin; myosin;
troponin; tropomyosin
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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