Description
Title: Different Sesquiterpene Analogues’ Acetylcholinesterase Inhibitory Potential for Alzheimer’s Disease Treatment
Abstract: Alzheimer’s disease (AD) is a slowly progressing, irreversible brain condition that affects almost every fifth person in the world (aged > 80). The World Health Organization (WHO) also reported that, by 2030, the prevalence of this disease will have significantly increased (up to double). The One of the primary causes for the occurrence and progression of this disorder is thought to be poor cholinergic transmission at the synapses. Commercially available acetylcholine (ACh) inhibitors made from natural substances, including galantamine and rivastigmine, are used to treat AD. Biomolecules with a wide range of structural variations, like sesquiterpenes, are the source of a wide range of pharmacological properties. Different sesquiterpenes’ potential as anticholinesterase has been explored. examined in this piece. For this, various databases were searched using terms like “sesquiterpenes+acetylcholinesterase,” primarily in PubMed, Scopus, and Web of Science. in the surveyed time period, and “sesquiterpenes+cholinesterase+inhibitors” (2010–2020). In the past ten years, a wealth of literature has emerged that supports the possibility that different sesquiterpenes can enhance cholinergic transmission by inhibiting AChE. Following data analysis, it was discovered that 12 compounds, out of a total of 58 sesquiterpenes, were reported to have an IC50 value of less than 9 M and can be thought of as potential candidates for the enhancement of learning and memory. Sesquiterpenes are a significant group of terpenoids that have been found to have a wide range of biological activities. According to the review’s findings, sesquiterpenes from herbs, like amberboin and lipidiol, may provide new, useful compounds for the potential prevention and treatment of AD.
Keywords: cognition; coumarins; lactones; phytochemicals; neurodegeneration; acetylcholinesterase; Alzheimer’s disease
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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