Description
Title: Alzheimer’s Disease and Dysbiosis: What Part Does Chronic Stress Play?
Abstract: Alzheimer’s disease (AD) is a neuropsychiatric, pathological condition that worsens the quality of geriatric lives. It is an incurable condition. Aggregated senile amyloid plaques, neurofibrillary tangles, neuronal loss, gliosis, oxidative stress, dysfunctional neurotransmitters, and bioenergetic deficits are the hallmarks of AD. It has been acknowledged that changes in GIT composition and harmony play a significant and intriguing role in neuronal pathologies, including AD. The oxidoreductase status, inflammation, immune system, and endocrine system are all regulated and influenced by microbiota. has the potential to affect the cognitive domain. Numerous studies demonstrate that microbiota regulates neuronal plasticity and neuronal development, and they link altered and dysfunctional microbiota to everything from simple infections to complex diseases like psychosis and neurodegeneration. Dysbiosis, an altered state of the microbiota, may have an impact on cognitive processes, stress response, and behavior. There is a distinct role for chronic stress in the progression of the pathological process. interacts at various physiological levels and has a direct impact on how AD pathology develops. Chronic stress-modulated changes influence the well-known pathological AD markers, but they also have an impact on the gut-brain axis thanks to a number of downstream signaling mechanisms that modify the microbial commensals of the gastrointestinal tract (GIT). According to a wealth of research, long-term stressors have a variety of effects on the microbiota’s physiological functions, metabolic processes, and composition. The goal of the current manuscript is to clarify the mechanistic mechanisms by which stress causes dysbiosis, which then intensifies the neuropathological chain reaction that results in AD. An area of potential research in the direction of treating AD appears to be the stress-dysbiosis axis.
Keywords: Alzheimer’s disease; microbiota; probiotics; chronic stress; glucocorticoids; HPA Axis
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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