Description
Title: Vesicles and Extracellular Matrix Change the Breast Tumor Microenvironment
Abstract: New research has revealed multiple functions for the extracellular matrix (ECM), a part of the tumor microenvironment (TME), in the initiation, progression, and metastasis of breast cancer. In addition to the breast ECM’s biophysical characteristics and biochemical makeup, signaling molecules play a crucial role in preserving homeostasis and are crucial for immune evasion and tumor progression in the breast TME. Extracellular Vesicles (EVs), the messengers that transmit information between cells and their microenvironment via signaling molecules, are only recently beginning to draw interest in the field of breast cancer research. In this extensive review, we first give an overview of the role of ECM in the development of breast cancer and the changes that take place in the TME during this process. Also covered is the crucial role that EVs and their biomolecular constituents play in the development and metastasis of breast cancer. Finally, We go over how these extracellular components affect treatment outcomes as well as any potential biomedical or clinical uses for them.
Keywords: breast cancer; extracellular matrix; extracellular vesicles
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Bioengineering
Writer Experience: 20+ Years
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