Description
Title: Pediatric Brain Tumor Preclinical Models: Moving Forward
Abstract: A brain tumor is found in five out of every 100,000 kids between the ages of 0 and 19 years old. These children are being treated with drugs meant for adults, which are extremely harmful to a growing brain. A lifetime of diminished physical, psychological, and cognitive abilities is highly likely for those who survive. There isn’t a single drug that was created specifically for pediatric patients, despite great effort. Preclinical research and the development of clinically relevant ideas are severely constrained by stagnant government funding and a lack of financial incentives for the pharmaceutical industry. applicable models for children’s brain tumors. As more data are gathered, the need for developing specific models suitable for predictive drug screening grows as disease sub-groups based on molecular heterogeneity are recognized. Preclinical methods will help in overcoming these obstacles. require constant improvement. The benefits and drawbacks of in vitro and in vivo preclinical pediatric brain tumor models are discussed in this review, along with potential fixes based on tried-and-true, up-to-date, and upcoming methods for enhancing clinical relevance.
Keywords: preclinical; in vitro models; animal models; pediatric brain tumors
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Bioengineering
Writer Experience: 20+ Years
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