Research Paper on Colon and Rectum Macro- and Micro-Mechanics I: Experimental Support

Description

Title: Colon and Rectum Macro- and Micro-Mechanics I: Experimental Support

Abstract: The large intestine, which includes the colon and rectum, has altered mechanical movement and is deformed in many lower gastrointestinal diseases. The main reason patients come to see visceral pain, which reliably elicits mechanical distension rather than non-mechanical stimuli like inflammation or heating, is experienced in gastrointestinal clinics. The large animal’s macroscopic biomechanics Mechanical tests and microscopic imaging of the load-bearing components, such as intestinal collagen and muscle fibers, were used to characterize the intestine. The muscularis propria and submucosal areas of the large intestine are areas with high mechanical stresses. and myenteric neural plexuses, demonstrating a functional connection between enteric neurons and intestinal structural biomechanics. We systematically compiled experimental data on the colon and rectum’s macro- and micro-scale biomechanics in both health and disease for this review. and illness. We reviewed the colon’s and the rectum’s diverse mechanical characteristics and looked at the imaging techniques used to describe the collagen fibers in the intestinal wall. We also talked about the colon and rectum’s various layers containing both intrinsic and extrinsic neural tissues. By investigating the interaction between tissue biomechanics and enteric neurons, this review lays the groundwork for future developments in intestinal biomechanics.

Keywords: colorectum; large intestine; mechanotransduction; multi-layered; experiments

Paper Quality: SCOPUS / Web of Science Level Research Paper

Subject: Bioengineering

Writer Experience: 20+ Years

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