Research Paper on Engineering Glial Cell Behavior to Promote Neural Regeneration with Electrospun Fiber Scaffolds

Description

Title: Engineering Glial Cell Behavior to Promote Neural Regeneration with Electrospun Fiber Scaffolds

Abstract: In order to create biocompatible, biodegradable scaffolds for tissue engineering applications, nano- or micro-diameter fibers are produced using the fabrication technique of electrospinning. Because they closely resemble the structure of the extracellular matrix of the nervous system and offer contact guidance for regenerating axons, electrospun fiber scaffolds are advantageous for neural regeneration. Non-neuronal regulatory cells called glia control regeneration in the injured nervous system and uphold homeostasis in the healthy nervous system. Electrospun fiber scaffolds have a variety of properties that can be engineered to produce the desired glial cell response to injury, including fiber alignment, diameter, surface nanotopography, and surface chemistry. Additionally, drugs, nucleic acids, or proteins can be incorporated into electrospun fibers to provide a localized, sustained release of such therapeutics, changing the phenotype of glial cells to better support regeneration. The effects of electrospun fiber alignment, diameter, surface nanotopography, surface functionalization, and therapeutic delivery on Schwann cells in the peripheral nervous system and astrocytes, oligodendrocytes, and microglia in the central nervous system both in vitro and in vivo are covered for the first time in this review. Designing and improving electrospun fiber scaffolds can be done using the information that is provided. to better regenerate the nervous system by focusing on glial cell response.

Keywords: glia; electrospun fibers; Schwann cells; astrocytes; oligodendrocytes; microglia

Paper Quality: SCOPUS / Web of Science Level Research Paper

Subject: Bioengineering

Writer Experience: 20+ Years

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