Description
Title: A Systematic Review of Collagen-Based Electrospun Materials for Tissue Engineering
Abstract: In many tissue engineering applications, collagen is a crucial component of the extracellular matrix (ECM) found in organs and tissues all over the body. Collagen can be electrospun to create scaffolds with a wide range of shapes, fiber diameters, and porosities that mimic the native ECM. To shed light on the relationship between source material, solvent, crosslinking technique, and functional outcomes, this systematic review will compile data from manuscripts on electro spun collagen and tissue engineering that are currently available. Most frequently, D-banding was seen in electrospun collagen made from collagen type I isolated from calfskin, which was frequently isolated in the lab and had quick solution solubilization times. All of the physical and chemical crosslinking techniques used resulted in increased strength and resistance to deterioration. When using shortened rinsing protocols and high crosslinking agent concentrations, cytotoxicity was seen. In vitro and in vivo engineered tissues could be formed using collagen and collagen-based scaffolds with a high degree of structural resemblance to native tissues.
Keywords: collagen; electrospinning; tissue engineering
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Bioengineering
Writer Experience: 20+ Years
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