Description
Title: Technologies for Blood Plasma Self-Separation During Self-Driven Flow in Microfluidic Platforms
Abstract: Due to the fact that blood plasma contains a variety of biomarkers, it is the biofluid that is most frequently used in biomedical analysis and disease diagnosis. Centrifugation, which is time-consuming and off-chip, is still used to separate the majority of blood plasma. As a result, a successful microfluidic blood plasma separation platform is drawing attention from researchers all over the world in the Lab-on-a-Chip (LOC) field. Active and passive self-separation are the two main categories used to classify blood plasma self-separation technologies. Contrary to active self-separation technologies Only microchannel geometry, microfluidic phenomena, and hydrodynamic forces are used in active self-separation. The capillary flow, which is produced by the characteristics of the channel surface and its interaction with the fluid, is what propels passive self-separation devices. In contrast to Due to their ease of fabrication, portability, and user-friendliness, active plasma separation techniques and passive plasma separation methods are more frequently used in the microfluidic platform. We outline some experimental details and tools to take advantage of these effects as well as a thorough review of the mechanisms underlying passive self-separation technologies. These technologies and devices’ capabilities, restrictions, and difficulties are also evaluated and discussed.
Keywords: passive self-separation; microfluidics; microfiltration; sedimentation; Dean vortex; hydrophilicity
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Bioengineering
Writer Experience: 20+ Years
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