Description
Title: Musculoskeletal Disorders Biofabrication Strategies: Evolution to Clinical Applications
Abstract: The use of biofabrication has become a popular method for customizing medical care and developing fresh remedies for common diseases and organ damage. Although it has made significant progress in a variety of fields, including skin grafting, drug testing, and cancer research, there are still few clinical applications of it for the treatment of musculoskeletal tissue disorders. Despite a number of in vitro Despite advances over the past ten years, palliative care and surgical interventions are still the only options for standard musculoskeletal treatments, which have limited biological functionality and long-term effects. Studying connections between fundamental science and other disciplines is crucial to better understanding this lack of translation. The translational barriers and changing frameworks for this utterly disruptive technology known as biofabrication present difficulties and developments. Thus, the processing stage of biofabrication is thoroughly examined in this review paper, with a focus on the bioinks appropriate for creating musculoskeletal tissue. and the patterns of their use. To address the shortcomings of sole biomaterials, this also includes underlying composite bioink strategies. We also discuss recent developments in the field of biofabrication that have been made to address persistent problems, such as controlled To aid in the biofabrication of more clinically applicable constructs, growth factors are delivered and spatially graded biological and structural scaffolds are created. We examine regulatory pathways, clinical translation challenges, clinical application of biofabricated musculoskeletal structures, and opportunities that are currently most accessible to clinical translation. In this article, we discuss the future of biofabrication and the general difficulties that must be overcome in order to achieve clinical relevance.
Keywords: additive manufacturing; 3D bioprinting; smart hydrogels; biomaterials; tissue engineering; musculoskeletal disorders
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Bioengineering
Writer Experience: 20+ Years
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