Description
Title: Sensing and Metabolic Engineering of N-Acetylglucosamine to Reduce Human and Plant Pathogens
Abstract: Pathogens that affect both humans and plants have evolved to use a variety of carbon sources. The amino sugar N-acetylglucosamine (GlcNAc) is one of the main carbon sources used by a number of human and phytopathogens. Numerous pathogen virulence genes are regulated by glucNAc. In actuality, GlcNAc catabolism controls the pathogenesis and virulence of a number of human pathogens, such as Candida albicans, Vibrio cholerae, and Leishmania. mycobacterium, Magnaporthe oryzae, and other phytopathogens. Additionally, GlcNAc is a well-known structural element of the cell walls of numerous bacterial and fungal pathogens, indicating a potential role in cell signaling. Numerous studies have been carried out in the last few decades to investigate GlcNAc sensing, signaling, and metabolism to better comprehend the roles of GlcNAc in pathogenesis and to identify new drug targets. We present recent findings on GlcNAc-mediated cell signaling and pathogenesis in this review. We also discuss how the pathogens’ virulence can be reduced by targeting the GlcNAc metabolic pathway, which will help to reduce disease prevalence and crop productivity.
Keywords: N-Acetylglucosamine; pathogens; virulence; colonization; NAG1; DAC1; HXK1; NGT1;chitin; plant immunity
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Bioengineering
Writer Experience: 20+ Years
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