Description
Title: The “Omics'” Diagnostic and Therapeutic Functions in Hypoxic-Ischemic Encephalopathy in Newborns
Abstract: Despite the increased accessibility of diagnostic and therapeutic tools, perinatal asphyxia and neonatal encephalopathy continue to be major causes of neonatal mortality and contribute to neurological and intellectual disabilities globally. The current strategy for improving diagnosis and prognosis of the outcome in neonatal hypoxic-ischemic encephalopathy (HIE) using bioengineering methods uses a combination of clinical data, neuroimaging, and biochemical parameters. Traditional biomarkers are not very helpful in this clinical condition, which presents as a multifactorial and variable phenotype. Novel “omics” systems based on biological principles (genomics, transcriptome, Identifying biomarkers linked to brain and other tissue injuries may aid in predicting the severity of the disease in HIE (e.g., through metabolomics and proteomics). Future neuroprotective treatment approaches are likely to include biomarker studies based on omics technologies, which will make it easier to evaluate the effectiveness of the intervention and its long-term efficacy. This article reviews the functions of various omics as HIE biomarkers and summarizes our current understanding of the clinical use of various omics molecules as novel biomarkers for neonatal brain injury. This review could help us develop more effective interventions for the HIE’s diagnostic and therapeutic aspects.
Keywords: hypoxic–ischemic encephalopathy; genomics; proteomics; metabolomics; biomarkers; omics
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Bioengineering
Writer Experience: 20+ Years
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