Description
Title: Molecular Understanding of Annexin A2’s Potential Contribution to COVID-19 Pathogenesis and Post-Infection Complications
Abstract: Over 235 million people have been infected with SARS-CoV-2, which has also claimed the lives of over 4.8 million people worldwide. Although vaccines have been created for prophylactic management, the viral infection is not currently being treated with any antivirals that have been clinically validated. The periodic outbreak of mutated SARS-CoV-2 and a lack of understanding of the molecular mechanisms underlying viral pathogenesis and post-infection complications have slowed down efforts worldwide to develop effective drugs. In this regard, it has been discussed how Annexin A2, a phospholipid-binding protein related to lipid rafts, affects SARS-CoV-2 attachment, internalization, and replication. In order to find the molecular interactions, we performed in silico docking of viral spike glycoprotein and RNA-dependent RNA polymerase with human AnxA2. This is in addition to the evidence from published literature. Overall, this review offers molecular insights into a potential role for AnxA2 in the pathogenesis of SARS-CoV-2 and post-infection complications, particularly thrombosis, cytokine storm, and insulin resistance.
Keywords: Annexin A2; COVID-19; cytokine storm; infection; insulin resistance; pathogenesis;SARS-CoV-2; thrombosis
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biology
Writer Experience: 20+ Years
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