Description
Title: Potential Therapy for SARS-CoV-2 Immunothrombosis with PAD Inhibitors
Abstract: Since the discovery of SARS-CoV-2 in December 2019, the virus’s dynamic nature has led to the evolution of a number of variants, including the more recent mu variant and the more common delta variant. It is crucial that researchers embrace the development of pharmacotherapeutics specific to SARS-CoV-2 pathophysiology given the variety of mutant strains that pose challenges to vaccine efficacy. In COVID-19 patients, neutrophil extracellular traps and their components, such as citrullinated histones, show a linear relationship with thrombotic manifestations. A group of enzymes known as peptidylarginine deiminases (PADs) are involved in the citrullination of histone arginine residues to produce NETs. Through mediating the formation of NETs, PAD inhibitors, more specifically PAD-4 inhibitors, offer significant pharmacotherapeutic potential for treating a variety of inflammatory diseases, including COVID-19. Although there are many PAD-4 inhibitors, the clinical application of these inhibitors to treat thrombotic complications in COVID-19 patients has not yet been thoroughly investigated in the literature. The clinical importance of PAD-4 inhibitors in reducing thrombotic complications in inflammatory disorders like COVID-19 is discussed in this review article, and it is suggested that these inhibitors may be helpful in treating the underlying cause of SARS-CoV-2 immunothrombosis.
Keywords: SARS-CoV2; COVID-19; PAD; NET
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biology
Writer Experience: 20+ Years
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